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Our Ingredients and selection criteria
BioPSI’ ingredients have been selected using the following strict standard of 13 criteria:
1. They have the ability to enhance neurological processes and impact aging mechanisms (aka “hallmarks of aging”) There are many different mechanisms that cause us to age and that when slowed down, can keep us younger and sharper for longer.
2. They impact multiple brain mechanisms at the same time. Ideally, an ingredient influences not just one, but multiple mechanisms.
3. They have been able to affect executive functioning and extend lifespan in various animal models, hinting at conserved evolutionary pathways.* (*The ingredients extend lifespan not in just one animal model, but in different species, like C.elegans (a little worm often used in aging research), yeast, fruit flies, or mice)
4. They are associated with reduced risk of mortality in humans*
*Ideally, people who take specific ingredients have reduced mortality.
5. They are associated with reduced risk of different neurological and aging-related diseases*
*A substance that can reduce the risk of different diseases and impact aging simultaneously is likely to act on an underlying mechanism that unites them, namely cognitive aging itself.
6. They are recognized as safe by FDA, EFSA and other organizations*
7. They are 100% nature-based*
*100% nature-based meaning having been present alongside human evolution, and NOT novel man-made, lab-made molecules.
8. They, or a chemical they stimulate, are found in the human body, but levels decrease with age
9. They have a (VERY) low side effect profile*
*The substances are known to cause very little side effects (if any), and NO serious side effects, even at greater dosages. Substances have a (VERY) limited list of indications with commonly known/used drugs or other natural supplements.
10. They have been used for many decades in humans without serious side-effects*
*Ideally, the substances also have already been used for decades or even centuries without serious side-effects or issues.
11. Highly synergistic with all other compounds in the formulation in which they are intended.
12. Large volume of peer-reviewed scientific findings to support their efficacy in the formulation in which they are intended.
13. High bio-availability, or proven methodology to make the compound highly bio-available.
Our Cornerstone Ingredients
Astragalus Root (as Cycloastragenol)
Astragalus has been used for centuries for its positive effects on the immune system, liver, and cardiovascular system. However in the last 15 years, much more significant scientific findings have been documented specific to the root of the Astragalus plant, and even more specific, a compound contained within the root - cycloastragenol. The scientific findings
Fisetin
Fisetin is a naturally occurring substance found in fruits and vegetables like strawberries, apples and grapes, and is a powerful senolytic. “Senolytics” are substances that clear senescent cells, the damaged cells that accumulate in the body during aging and secrete substances that damage normal, healthy cells. Fisetin has many other beneficial effects, such as contributing to the healt
Acetyl-L-carnitine
Acetyl-L-carnitine is important for many body processes. L-carnitine is made in the human brain, liver, and kidneys. The body can convert L-carnitine to acetyl-L-carnitine and vice versa. Acetyl-L-carnitine is used for focus and energy, neuro-degenerative conditions, improving memory and cognitive function, treating mood disorders and depression, and reducing the signal of nerve
Functional Mushrooms
In recent years, study after study have proven various functional mushrooms to be powerful nootropics, demonstrating aweinspiring promise for neural plasticity, executive cognitive function enhancement, mitochondial energy promotion, increased cerebral blood flow, increases in gray matter, supporting the nervous and immune system, regulating blood pressure, and perhaps most stu
Pterostilbene
Pterostilbene, a natural substance found in blueberries, and is better absorbable and lasts longer in the body than resveratrol, a compound that has shown to extend lifespan in different species. Pterostilbene can target inflammation at a cellular level, induces autophagy, contributes to a healthy epigenome and DNA stability, amongst other significant benefits.
NICOTINAMIDE MONONUCLEOTIDE (NMN)
In humans, nicotinamide mononucleotide (NMN) increases levels of NAD+, which is needed for proper DNA repair and to maintain the epigenome. NMN has shown to support a healthy metabolism in humans, and improve muscle strength and performance in the elderly. NMN slows down various aging processes, and enhances immune and cognitive function..
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